Sitagliptin Intermediate
Chemical Name: 2,4,5-Trifluorophenylacetic acid
Formula: C8H5F3O2
Mol Wt: 190.12
CAS No. 209995-38-0
Sitagliptin phosphate is the active pharmaceutical ingredient of brand drug Januvia which is an oral DDP-4 inhibitor which is used to treat diabet disease. Januvia was approved by US FDA in 2006. 2,4,5-Trifluorophenylacetic acid is the key starting material to produce the API (active pharmaceutical ingredient) sitagliptin phosphate.
Specs:
Appearance: white to brown solid, free from visible contamination
Water content: 0.5% max
HPLC Purity: 99.0% min
Single Impurity: 0.5% max
Total Impurities: 1.0% max
Production complies with GMP standard