Nicotinamide

Nicotinamide, also known as Niacinamide, vitamin B3 or vitamin PP, is a water-soluble vitamin, belonging to B group vitamins, which is a component of coenzyme I (nicotinamide adenine dinucleotide, NADP) and coenzyme II (nicotinamide adenine dinucleotide phosphate, NADP). Nicotinamide in these two coenzyme structures in human body has reversible hydrogenation and dehydrogenation characteristics and plays an important role in biological oxidation It can promote the process of tissue respiration, biological oxidation and metabolism, and is of great significance to maintain the integrity of normal tissues, especially the skin, digestive tract and nervous system. In case of deficiency, due to the influence of cell respiration and metabolism, this product is mainly used for the prevention and treatment of pellagra, stomatitis, glossitis, etc. In addition, the product can also prevent and treat heart block, improve the function of sinoatrial node and fast experimental arrhythmia, and significantly improve verapamil induced heart rate slowing and atrioventricular block. Clinically, it is used for arrhythmias accompanied by coronary heart disease, viral myocarditis, rheumatic heart disease and a few digitalis poisoning (most of which are only used when other drugs are ineffective). Generally, it has obvious effect on all degrees of atrioventricular block. Basically, after treatment, the block can disappear, and it also has obvious effect on sick sinus syndrome. Chemical book has curative effect on bundle branch block Poor. The product is absorbed by stomach and intestines, absorbed faster by intramuscular injection, and distributed to all tissues of the body after absorption. T1 / 2 is 45 minutes. After liver metabolism, most of them were metabolized into n-methylnicotinamide. Only a small amount of treatment was excreted from urine in the original form, and the excretion increased when the dosage exceeded the need. If the n-methylnicotinamide in the urine is less than 4 mg per day, it indicates the lack of nicotinamide. Nicotinamide and nicotinic acid are collectively called vitamin pp. nicotinic acid participates in the metabolism process in the form of nicotinamide in animals, and they have the same vitamin activity. It is white crystalline powder, odorless or almost odorless, with bitter taste. Soluble in water or ethanol, soluble in glycerin. It has weak hygroscopicity. It is stable and can resist acid, alkali and high temperature. Nature mainly exists in the husk of Cereals, yeast, peanut, meat, animal organs and viscera, milk and green leafy vegetables. Tryptophan can be synthesized in human body, but the efficiency is very low. Nicotinic acid can be synthesized by Escherichia coli in the intestine and then converted into nicotinamide. It can prevent and treat pellagra, symmetrical dermatitis, stomatitis, glossitis, anorexia, sun dermatitis, liver disease, coronary heart disease, atrioventricular block, sick sinus syndrome, diarrhea, neuritis and dementia.